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ISCO scientists have created the first parthenogenic, homozygous stem cell line that can be a source of therapeutic cells with minimal immune rejection after transplantation into hundreds of millions of individuals of differing genders, ages and racial background. This offers the potential to create the first true stem cell bank, UniStemCellTM. ISCO also produces and markets specialized cells and growth media for therapeutic research worldwide through its subsidiary Lifeline Cell Technology, and cell-based skin care products through its subsidiary Lifeline Skin Care. More information is available at <a href="http://www.internationalstemcell.com" rel="nofollow">http://www.internationalstemcell.com</a> </p> <p>To subscribe to receive ongoing corporate communications, please click on the following link:http://www.b2i.us/irpass.asp?BzID=1468&#38;to=ea&#38;s=0.</p> <p>Forward-looking Statements<br /> Statements pertaining to anticipated developments, research and development goals and related potential therapeutic treatments, the potential benefits of products, and other opportunities for the company and its subsidiaries, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward- looking statements. Any statements that are not historical fact (including, but not limited to statements that contain words such as "will," "believes," "plans," "anticipates," "expects," "estimates,") should also be considered to be forward-looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in the development and/or commercialization of potential products and the management of collaborations, regulatory approvals, need and ability to obtain future capital, application of capital resources among competing uses, and maintenance of intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the company's business, particularly those mentioned in the cautionary statements found in the company's Securities and Exchange Commission filings. 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The InDanio screening system can be used, for example, to functionally characterize ‘orphan’ receptors – those for which their natural ligands or specific function are unknown – and thus qualify them as potential targets for drug discovery. The system can also be used to screen compound libraries in order to identify and refine potential new drugs that target NR proteins.<br /> NRs are found inside cells and are responsible for sensing the presence of hormones and other molecules. They regulate the expression in the cell of a number of genes involved in homeostatic, metabolic and reproductive processes. NRs regulate the expression in the cell of a number of processes, and they also represent an important and successful class of drug targets implicated in some of the most prevalent diseases, including immune disorders, obesity, diabetes and cancer. A study four years ago determined that one seventh of drugs approved by the U.S. Food and Drug Administration (FDA) target nuclear receptors, and the top ten selling NR-based drugs combined represent worldwide annual sales of over USD $16 billion. Although many NRs have been targeted successfully, most of them have not been, and one third of them are still orphans.<br /> InDanio was founded by Dr. Henry Krause, a professor in the Banting and Best Department of Medical Research at the University of Toronto, and Dr. Jens Tiefenbach, a post-doctoral fellow working with Dr. Krause and is based on the IP portfolio generated by their research.</p> <p>“The OGI investment will allow InDanio to characterize the function of ill-understood members of the NR family and thus form the basis for establishing commercial partnerships to further characterize such receptors and develop drugs targeting them,” commented Dr. Paul Chipperton, member of the InDanio board of directors and CEO of Profound Medical. “With a more efficient and comprehensive approach to probing the NR receptors, there is a tremendous opportunity to develop new therapeutic avenues into the NR family.”</p> <p>InDanio’s zebrafish ligand trap (LT) technology and LT drug discovery platform will take advantage of the fact that zebrafish are transparent in early stages of development, thus allowing for the use of fluorescent protein markers. Many drugs never reach the marketplace because they fail toxicology tests or have other unintended effects on the body. Currently, in vitro testing relies on measuring simple chemical interactions to gauge a drug’s effectiveness, but this is often not an effective predictor of how drugs will affect living organisms. By beginning the screening process with in vivo assays using live zebrafish, more information on a drug’s effectiveness, toxicology and other side-effects can be gathered in advance of and to better inform downstream clinical trials.</p> <p>“InDanio is in an excellent position to capitalize on the significant work undertaken by the academic and pharma sectors over the past 20 years in characterizing NR proteins and developing compound libraries targeting these proteins,” commented Dr. Christian Burks, President and CEO of OGI. “Their screening system should provide novel, productive information on natural ligands, tissue and developmental specificity of natural or xenobiotic compounds, and whether or not a compound binds multiple receptors.”</p> <p>OGI’s PBDF program invests in opportunities — based in genomics, proteomics or associated technologies — that fall in the proof-of-principle (validation) phase of research and that have the short-term potential to secure a significant next step towards the marketplace. Previous recipients have included Ontario universities, research institutes and companies. Applications are due in January 2011 for the next round of PBDF investments.<br /> -30-</p> <p>InDanio information: <a href="http://www.inDanio.com" rel="nofollow">http://www.inDanio.com</a> &#38; <a href="http://www.g-sin.com/home/search?_keywords=indanio" rel="nofollow">http://www.g-sin.com/home/search?_keywords=indanio</a></p> <p>InDanio NR screening system in zebrafish: <a href="http://www.plosone.org/article/info:doi%2F10.1371%2Fjournal.pone.0009797" rel="nofollow">http://www.plosone.org/article/info:doi%2F10.1371%2Fjournal.pone.0009797</a></p> <p>About OGI<br /> The Ontario Genomics Institute (OGI) is a private, not-for-profit corporation focused on using world-class research to create strategic genomics resources and accelerate Ontario’s development of a globally-competitive life sciences sector. Through its relationship with Genome Canada, the Ontario Ministry of Research and Innovation (MRI), and other private and public sector partners, OGI works to: identify, attract and support investment in Ontario-led genomics research; catalyze access to and the impact of genomics resources; and, raise the visibility of genomics as well as its impact and associated issues.<br /> For more information on OGI, please visit <a href="http://www.OntarioGenomics.ca" rel="nofollow">http://www.OntarioGenomics.ca</a> </p> <p>OGI media enquiries: Alastair Harris-Cartwright, Corporate Communications Manager, T: +1 (416) 673-6582.<br /> E: <a href="mailto:aharriscartwright@OntarioGenomics.ca">aharriscartwright@OntarioGenomics.ca</a></p> <p>Information about Ontario’s genomics sector, including companies, projects &#38; people: <a href="http://www.g-sin.com" rel="nofollow">http://www.g-sin.com</a></p> <p>PBDF program: <a href="http://www.ontariogenomics.ca/business-development/pre-commercialization-business-development-fund" rel="nofollow">http://www.ontariogenomics.ca/business-development/pre-commercialization-business-development-fund</a><br /> Rhonda Tannenbaum, Director of Business Development, T: +1 (416) 673-6586<br /> E: <a href="mailto:rtannenbaum@OntarioGenomics.ca">rtannenbaum@OntarioGenomics.ca</a> </p> http://biotechbistro.com/forum/topic/attending-bio#post-16 Fri, 03 Apr 2009 13:33:21 +0000 dperrino 16@http://biotechbistro.com/forum/ <p>Great networking opportunity during BIO in Atlanta. 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